Caveolins in cholesterol trafficking and signal transduction: Implications for human disease

被引：46

作者：

Schlegel, A

Pestell, RG

Lisanti, MP

机构：

[1] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Albert Einstein Comprehens Canc Ctr, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA

[4] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2000年 / 5卷

关键词：

caveolin; caveolae; cholesterol; signal transduction; cancer; review;

D O I：

10.2741/schlegel

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caveolins are a family of proteins that coat the cytoplasmic face of caveolae, vesicular invaginations of the plasma membrane. These proteins are central to the organization of the proteins and lipids that reside in caveolae. Caveolins transport cholesterol to and from caveolae, and they regulate the activity of signaling proteins that reside in caveolae. Through studying the genes encoding the caveolae coat proteins, we have learned much about how they perform these multiple functions.

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收藏

页码：D929 / D937

页数：9

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