Genetic variation in the 5-HT5A receptor gene in patients with bipolar disorder and major depression

被引：23

作者：

Arias, B

Collier, DA

Gastó, C

Pintor, L

Gutiérrez, B

Vallès, V

Fañanás, L

机构：

[1] Univ Barcelona, Fac Biol, Dept Anim Biol, Unitat Antropol, E-08028 Barcelona, Spain

[2] Hosp Clin Barcelona, Ctr Salut Mental Esquerre Eixample, Barcelona, Spain

[3] Inst Psychiat, Div Psychol Med, London, England

[4] Consorci Sanitari Terrassa, Serv Psiquiatria, Barcelona, Spain

来源：

NEUROSCIENCE LETTERS | 2001年 / 303卷 / 02期

关键词：

major depression; bipolar disorder; 5-HT5A receptor; association study;

D O I：

10.1016/S0304-3940(01)01701-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the present study, genetic variation of the 5-HT5A receptor was analyzed in patients affected by affective disorders and healthy controls. The sample consisted of 181 patients with major depression, 88 patients with bipolar affective disorder (BP) and 157 unrelated controls (C), all of Spanish origin. Two polymorphisms (-19G/C and 12A/T) in the 5-HT5A receptor gene were analyzed by polymerase chain reaction amplification and subsequent enzyme digestion. No genotype, allele or haplotype differences were found when we compared patients and controls. When clinical variables were considered as possible tools for detecting genetic heterogeneity, no differences were found. Our results suggest that the polymorphisms analyzed in the 5-HT5A receptor gene do not play a major role in the pathogenesis of affective disorders. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：111 / 114

页数：4

共 17 条

[1] Major depressive disorder in a community-based twin sample -: Are there different genetic and environmental contributions for men and women? [J].