Phosphorylation regulates calpain-mediated truncation of glutamate ionotropic receptors

被引：46

作者：

Bi, RF ^{[1
]}

Bi, XN ^{[1
]}

Baudry, M ^{[1
]}

机构：

[1] Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA

来源：

BRAIN RESEARCH | 1998年 / 797卷 / 01期

关键词：

calpain; glutamate; receptor; phosphorylation; plasticity;

D O I：

10.1016/S0006-8993(98)00433-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pre-incubation of synaptic membranes with phosphatase inhibitors significantly reduces the extent of calpain-mediated truncation of both GluR1 and NR2 subunits of AMPA and NMDA receptors, respectively. The same treatment did not modify calpain-mediated truncation of spectrin. These results might have important implications for mechanisms of synaptic plasticity as the balance of kinase/phosphatase activity and calpain has been proposed to regulate synaptic efficacy at glutamatergic synapses. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：154 / 158

页数：5

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