A European allele map of the C282Y mutation of hemochromatosis:: Celtic versus Viking origin of the mutation?

被引：60

作者：

Lucotte, G ^{[1
]}

Dieterlen, F ^{[1
]}

机构：

[1] Int Inst Anthropol, Paris, France

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2003年 / 31卷 / 02期

关键词：

hemochromatosis; HFE gene; C282Y mutation; populations in Europe; C282Y frequencies; C282Y allele map; Celtic and Viking origins;

D O I：

10.1016/S1079-9796(03)00133-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this new meta-analysis (to the end of 2002) is to compile the Y allele frequencies of the C282Y mutation of hereditary hemochromatosis (HFE gene) for 63 European populations, representing a total of 10,708 unrelated people concerning control samples. A new allele map of C282Y frequencies in Europe was constructed. The highest European frequencies are observed in the Celtic populations in Ireland, in the United Kingdom, and in France, but elevated frequencies are also observed in Scandinavia. (C) 2003 Elsevier Science (USA). All rights reserved.

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页码：262 / 267

页数：6

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