The Role of Syk/CARD9-Coupled C-Type Lectin Receptors in Immunity to Mycobacterium tuberculosis Infections

被引：38

作者：

Marakalala, Mohlopheni Jackson ^{[2
]}

Graham, Lisa M. ^{[2
]}

Brown, Gordon D. ^{[1
]}

机构：

[1] Univ Aberdeen, Aberdeen Fungal Grp, Sect Immunol & Infect, Div Appl Med,Inst Med Sci, Aberdeen AB25 2ZD, Scotland

[2] Univ Cape Town, Inst Infect Dis & Mol Med, Div Immunol, CLS, ZA-7925 Cape Town, South Africa

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2010年

基金：

英国医学研究理事会; 新加坡国家研究基金会; 英国惠康基金;

关键词：

BETA-GLUCAN RECEPTOR; PATTERN-RECOGNITION RECEPTOR; ADAPTER PROTEIN CARD9; TOLL-LIKE RECEPTORS; CANDIDA-ALBICANS; FUNGAL-INFECTION; ACTIVATING RECEPTOR; ANTIFUNGAL IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELLS;

D O I：

10.1155/2010/567571

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

There is increasing interest in understanding the mechanisms underlying the interactions that occur between Mycobacterium tuberculosis and host innate immune cells. These cells express pattern recognition receptors (PRRs) which recognise mycobacterial pathogen-associated molecular patterns (PAMPs) and which can influence the host immune response to the infection. Although many of the PRRs appear to be redundant in the control of M. tuberculosis infection in vivo, recent discoveries have revealed a key, nonredundant, role of the Syk/CARD9 signalling pathway in antimycobacterial immunity. Here we review these discoveries, as well as recent data investigating the role of the Syk/CARD9-coupled PRRs that have been implicated in mycobacterial recognition, including Dectin-1 and Mincle.

引用

页数：9

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