Functional studies of the MEN1 gene

被引：51

作者：

Chandrasekharappa, SC ^{[1
]}

Teh, BT

机构：

[1] NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA

[2] Van Andel Res Inst, Canc Genet Lab, Grand Rapids, MI USA

来源：

JOURNAL OF INTERNAL MEDICINE | 2003年 / 253卷 / 06期

关键词：

Jun D; menin; multiple endocrine neoplasia type 1 (MEN1); nuclear localization; protein interaction; tumour suppressor;

D O I：

10.1046/j.1365-2796.2003.01165.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple endocrine neoplasia type 1 is an autosomal dominant cancer syndrome affecting primarily parathyroid, enteropancreatic endocrine and pituitary tissues. The inactivating germline and somatic mutations spread throughout the gene and the accompanying loss of the second allele in tumours show that the MEN1 gene is a tumour suppressor. The MEN1 -encoded protein, menin, is a novel nuclear protein. Menin binds and alters JunD-, NF-kappaB-, Smad3-mediated transcriptional activation. The mouse Men1 knockout model mimicks the human MEN1 condition contributing to the understanding of tumorigenesis in MEN1.

引用

页码：606 / 615

页数：10

共 41 条

[1] Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription [J].

Agarwal, SK ;

Guru, SC ;

Heppner, C ;

Erdos, MR ;

Collins, RM ;

Park, SY ;

Saggar, S ;

Chandrasekharappa, SC ;

Collins, FS ;

Spiegel, AM ;

Marx, SJ ;

Burns, AL .

CELL, 1999, 96 (01) :143-152

[2] Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1 [J].

Bassett, JHD ;

Rashbass, P ;

Harding, B ;

Forbes, SA ;

Pannett, AAJ ;

Thakker, RV .

JOURNAL OF BONE AND MINERAL RESEARCH, 1999, 14 (01) :3-10

[3] FAMILIAL MULTIPLE ENDOCRINE NEOPLASIA TYPE-I - A NEW LOOK AT PATHOPHYSIOLOGY [J].

BRANDI, ML ;

MARX, SJ ;

AURBACH, GD ;

FITZPATRICK, LA .

ENDOCRINE REVIEWS, 1987, 8 (04) :391-405

[4] Mutational analysis of Portuguese families with multiple endocrine neoplasia type 1 reveals large germline deletions [J].

Cavaco, BM ;

Domingues, R ;

Bacelar, MC ;

Cardoso, H ;

Barros, L ;

Gomes, L ;

Ruas, MMA ;

Agapito, A ;

Garräo, A ;

Pannett, AAJ ;

Silva, JL ;

Sobrinho, LG ;

Thakker, RV ;

Leite, V .

CLINICAL ENDOCRINOLOGY, 2002, 56 (04) :465-473

[5]

Chandrasekharappa SC, 2001, FRONT HORM RES, V28, P50

[6] Positional cloning of the gene for multiple endocrine neoplasia-type 1 [J].

Chandrasekharappa, SC ;

Guru, SC ;

Manickam, P ;

Olufemi, SE ;

Collins, FS ;

EmmertBuck, MR ;

Debelenko, LV ;

Zhuang, ZP ;

Lubensky, IA ;

Liotta, LA ;

Crabtree, JS ;

Wang, YP ;

Roe, BA ;

Weisemann, J ;

Boguski, MS ;

Agarwal, SK ;

Kester, MB ;

Kim, YS ;

Heppner, C ;

Dong, QH ;

Spiegel, AM ;

Burns, AL ;

Marx, SJ .

SCIENCE, 1997, 276 (5311) :404-407

[7] THE E2F TRANSCRIPTION FACTOR IS A CELLULAR TARGET FOR THE RB PROTEIN [J].

CHELLAPPAN, SP ;

HIEBERT, S ;

MUDRYJ, M ;

HOROWITZ, JM ;

NEVINS, JR .

CELL, 1991, 65 (06) :1053-1061

[8] A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors [J].

Crabtree, JS ;

Scacheri, PC ;

Ward, JM ;

Garrett-Beal, L ;

Emmert-Buck, MR ;

Edgemon, KA ;

Lorang, D ;

Libutti, SK ;

Chandrasekharappa, SC ;

Marx, SJ ;

Spiegel, AM ;

Collins, FS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (03) :1118-1123

[9] Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanism [J].

Gobl, AE ;

Berg, M ;

Lopez-Egido, JR ;

Öberg, K ;

Skogseid, B ;

Westin, G .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1999, 1447 (01) :51-56

[10] Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene [J].

Guru, SC ;

Crabtree, JS ;

Brown, KD ;

Dunn, KJ ;

Manickam, P ;

Prasad, NB ;

Wangsa, D ;

Burns, AL ;

Spiegel, AM ;

Marx, SJ ;

Pavan, WJ ;

Collins, FS ;

Chandrasekharappa, SC .

MAMMALIAN GENOME, 1999, 10 (06) :592-596

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