Assessment of regional differences in intestinal fluid movement in the rat using a modified in situ single pass perfusion model

被引：8

作者：

Raoof, AA ^{[1
]}

Butler, J ^{[1
]}

Devane, JG ^{[1
]}

机构：

[1] Elan Pharmaceut Technol, IVIVR Cooperat Working Grp, Athlone, Ireland

来源：

PHARMACEUTICAL RESEARCH | 1998年 / 15卷 / 08期

关键词：

net water flux; regional fluid movement; single pass perfusion; antipyrine; rat;

D O I：

10.1023/A:1011920714784

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：1314 / 1316

页数：3

共 14 条

[1]

Chang Eugene B., 1994, P2027

[2] STUDIES OF THE DIFFERENT METABOLIC PATHWAYS OF ANTIPYRINE IN MAN - ORAL VERSUS IV ADMINISTRATION AND THE INFLUENCE OF URINARY COLLECTION TIME [J].

DANHOF, M ;

VANZUILEN, A ;

BOEIJINGA, JK ;

BREIMER, DD .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 21 (05) :433-441

[3] Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms [J].

Fagerholm, U ;

Lindahl, A ;

Lennernas, H .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1997, 49 (07) :687-690

[4] Comparison between permeability coefficients in rat and human jejunum [J].

Fagerholm, U ;

Johansson, M ;

Lennernas, H .

PHARMACEUTICAL RESEARCH, 1996, 13 (09) :1336-1342

[5] WATER AND ELECTROLYTE FLUX RATES IN DUODENUM, JEJUNUM, ILEUM AND COLON, AND EFFECTS OF OSMOLARITY [J].

GRIM, E .

AMERICAN JOURNAL OF DIGESTIVE DISEASES, 1962, 7 (01) :17-&

[6] IN-VITRO SYSTEMS FOR STUDYING INTESTINAL DRUG ABSORPTION [J].

HILLGREN, KM ;

KATO, A ;

BORCHARDT, RT .

MEDICINAL RESEARCH REVIEWS, 1995, 15 (02) :83-109

[7]

JOHNO I, 1985, INT J PHARM, V25, P255

[8] REGIONAL JEJUNAL PERFUSION, A NEW INVIVO APPROACH TO STUDY ORAL-DRUG ABSORPTION IN MAN [J].

LENNERNAS, H ;

AHRENSTEDT, O ;

HALLGREN, R ;

KNUTSON, L ;

RYDE, M ;

PAALZOW, LK .

PHARMACEUTICAL RESEARCH, 1992, 9 (10) :1243-1251

[9] DOES FLUID-FLOW ACROSS THE INTESTINAL-MUCOSA AFFECT QUANTITATIVE ORAL-DRUG ABSORPTION - IS IT TIME FOR A REEVALUATION [J].

LENNERNAS, H .

PHARMACEUTICAL RESEARCH, 1995, 12 (11) :1573-1582

[10] CONTRIBUTION OF SOLVENT DRAG TO INTESTINAL-ABSORPTION OF BASIC DRUGS AMIDOPYRINE AND ANTIPYRINE FROM JEJUNUM OF RAT [J].

OCHSENFAHRT, H ;

WINNE, D .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1974, 281 (02) :175-196

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