Malaria enhances expression of CC chemokine receptor 5 on placental macrophages

被引：62

作者：

Tkachuk, AN

Moormann, AM

Poore, JA

Rochford, RA

Chensue, SW

Mwapasa, V

Meshnick, SR

机构：

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Otolaryngol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA

[4] Case Western Reserve Univ, Sch Med, Div Geog Med, Cleveland, OH USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2001年 / 183卷 / 06期

关键词：

D O I：

10.1086/319248

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5(+) maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells.

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页码：967 / 972

页数：6

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