Disruption of white matter integrity in the inferior longitudinal fasciculus in adolescents with schizophrenia as revealed by fiber tractography

被引:146
作者
Ashtari, Manzar
Cottone, John
Ardekani, Babak A.
Cervellione, Kelly
Szeszko, Philip R.
Wu, Jinghui
Chen, Steven
Kumra, Sanjiv
机构
[1] Zucker Hillside Hosp, Dept Psychiat Res, Glen Oaks, NY USA
[2] Ctr Adv Brain Imaging, Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
[3] Jamaica Hosp Med, Dept Clin Res, Jamaica, NY USA
[4] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA
关键词
D O I
10.1001/archpsyc.64.11.1270
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Context: There is increasing evidence that schizophrenia is characterized by abnormalities in white matter. Objective: To investigate the integrity of white matter tracts in adolescents with schizophrenia. Design: Cross-sectional, case-control, whole-brain, voxel-based analysis and fiber tractography using diffusion tensor magnetic resonance imaging. Setting: University research institute. Participants: Forty-four individuals (age range, 11-18 years), 23 with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder and 21 demographically similar healthy controls. Main Outcome Measures: Fractional anisotropy, trace, and radial diffusivity of diffusion tensor and quantitative tractography. Results: Voxelwise analysis revealed that adolescents with schizophrenia had reduced fractional anisotropy within the left inferior temporal (P <. 001) and occipital (P <. 001) regions. Tractography was performed to extract the left and the right inferior longitudinal fasciculi (ILF). Measuring the mean diffusion indices along the left ILF, patients had significantly reduced fractional anisotropy (P <. 001) as well as significantly increased radial diffusivity (P <. 001) and trace (P=. 003) after adjusting for differences in a measure thought to reflect premorbid intelligence, Wide Range Achievement Test 3 reading scores. Exploratory analyses revealed that patients with a history of visual hallucinations had lower fractional anisotropy in the left ILF (P=. 02) than patients without visual hallucinations. Conclusion: Our findings, which benefited from greater image resolution and methodological control than previous studies conducted in adolescents with schizophrenia, provide strong evidence for lower white matter integrity in the left ILF, particularly for patients with a history of visual hallucinations.
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页码:1270 / 1280
页数:11
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