Lack of Socs2 expression causes the high-growth phenotype in mice

被引:97
作者
Horvat, S
Medrano, JF
机构
[1] Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland
[2] Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1006/geno.2000.6441
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Characterizing causal molecular defects in mouse models of overgrowth or dwarfism helps to identify the key genes and pathways that regulate the growth process. We report here the molecular basis for high growth (hg), a spontaneous mutation that causes a 30-50% increase in postnatal growth. We conclude that hg is an allele of the suppressor of cytokine signaling 2 (Socs2), a member of a family of regulators of cytokine signal transduction. We demonstrate mapping of Socs2 to the hg region, lack of Socs2 mRNA expression, a disruption of the Socs2 locus in high-growth (HG) mice, and a similarity of phenotypes of HG; mice and Socs2(-/-) mice generated by gene targeting, Characteristics of the HG phenotype suggest that Socs2 deficiency affects growth prenatally and postnatally most likely through deregulating the growth hormone (GH)/insulin-like growth factor I (IGF1), These results demonstrate a critical role for Socs2 in controlling growth, (C) 2001 Academic Press.
引用
收藏
页码:209 / 212
页数:4
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