MR Elastography-derived Stiffness: A 31omarker for Intervertebral Disc Degeneration

被引：39

作者：

Walter, Benjamin A. ^{[1
,2
]}

Mageswaran, Prasath ^{[1
,3
]}

Mo, Xiaokui ^{[4
]}

Boulter, Daniel J. ^{[5
]}

Mashaly, Hazem ^{[1
,6
]}

Nguyen, Xuan V. ^{[5
]}

Prevedello, Luciano M. ^{[5
]}

Thoman, William ^{[1
,6
]}

Raterman, Brian D. ^{[5
]}

Kalra, Prateek ^{[5
]}

Mendel, Ehud ^{[1
,6
]}

Marras, William S. ^{[1
,3
]}

Kolipaka, Arunark ^{[1
,2
,5
]}

机构：

[1] Ohio State Univ, Spine Res Inst, 395 W 12th Ave,4th Floor Radiol, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Biomed Engn, 395 W 12th Ave,4th Floor Radiol, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Integrated Syst Engn, 395 W 12th Ave,4th Floor Radiol, Columbus, OH 43210 USA

[4] Ohio State Univ, Dept Biomed Informat, 395 W 12th Ave,4th Floor Radiol, Columbus, OH 43210 USA

[5] Ohio State Univ, Dept Radiol, Wexner Med Ctr, Columbus, OH 43210 USA

[6] Ohio State Univ, Dept Neurol Surg, Columbus, OH 43210 USA

来源：

RADIOLOGY | 2017年 / 285卷 / 01期

关键词：

MAGNETIC-RESONANCE ELASTOGRAPHY; LUMBAR NUCLEUS PULPOSUS; MECHANICAL-PROPERTIES; AORTIC STIFFNESS; CARDIAC CYCLE; QUANTIFICATION; BEHAVIOR; LEVEL; AGE;

D O I：

10.1148/radiol.2017162287

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Purpose: To determine the repeatability of magnetic resonance (MR) elastography-derived shear stiffness measurements of the intervertebral disc (IVD) taken throughout the day and their relationship with IVD degeneration and subject age. Materials and Methods: In a cross-sectional study, in vivo lumbar MR elastography was performed once in the morning and once in the afternoon in 47 subjects without current low back pain (IVDs = 230; age range, 20-71 years) after obtaining written consent under approval of the institutional review board. The Pfirrmann degeneration grade and MR elastography-derived shear stiffness of the nucleus pulposus and annulus fibrosus regions of all lumbar IVDs were assessed by means of principal frequency analysis. One-way analysis of variance, paired t tests, concordance and Bland-Altman tests, and Pearson correlations were used to evaluate degeneration, diurnal changes, repeatability, and age effects, respectively. Results: There were no significant differences between morning and afternoon shear stiffness across all levels and there was very good technical repeatability between the morning and afternoon imaging results for both nucleus pulposus (R = 0.92) and annulus fibrosus (R = 0.83) regions. There was a significant increase in both nucleus pulposus and annulus fibrosus MR elastography-derived shear stiffness with increasing Pfirrmann degeneration grade (nucleus pulposus grade 1, 12.5 kPa +/- 1.3; grade 5, 16.5 kPa +/- 2.1; annulus fibrosus grade 1, 90.4 kPa +/- 9.3; grade 5, 120.1 kPa +/- 15.4), and there were weak correlations between shear stiffness and age across all levels (R = 0.32). Conclusion: Our results demonstrate that MR elastography-derived shear stiffness measurements are highly repeatable, weakly correlate with age, and increase with advancing IVD degeneration. These results suggest that MR elastography-derived shear stiffness may provide an objective biomarker of the IVD degeneration process. (C) RSNA, 2017

引用

页码：167 / 175

页数：9

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