Morphine's immunoregulatory actions are not shared by fentanyl

被引：60

作者：

Bilfinger, TV ^{[1
]}

Fimiani, C

Stefano, GB

机构：

[1] SUNY Stony Brook, Dept Surg, Univ Hosp & Med Ctr, Cardiac Res Program, Stony Brook, NY 11794 USA

[2] SUNY Coll Old Westbury, Neurosci Res Inst, Old Westbury, NY 11568 USA

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 1998年 / 64卷

关键词：

fentanyl; analgesia; morphine; nitric oxide; inflammation; cell adhesion;

D O I：

10.1016/S0167-5273(98)00037-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fentanyl is a commonly used narcotic agent in anesthesia. It has strong analgesic properties which it shares with morphine. Unlike morphine, it does not possess the ability to bind to the mu(3) receptor, and therefore does not have the ability to influence nitric oxide release as measured amperometrically. Cell adhesion also is not influenced. As a result, it also lacks the ability to downregulate the inflammatory response associated with surgery, especially cardiopulmonary bypass. (C) 1998 Elsevier Science Ireland Ltd.

引用

收藏

页码：S61 / S66

页数：6

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