Effects of chronic food restriction and exercise training on the recovery of cardiac function following ischemia

被引:25
作者
Broderick, TL
Driedzic, WR
Gillis, M
Jacob, J
Belke, T
机构
[1] Midwestern Univ, Dept Physiol, Glendale, AZ 85308 USA
[2] Mem Univ Newfoundland, Ctr Ocean Sci, St John, NF, Canada
[3] Mt Allison Univ, Dept Biol & Biochem, Sackville, NB E0A 3C0, Canada
[4] Mt Allison Univ, Dept Psychol, Sackville, NB E0A 3C0, Canada
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2001年 / 56卷 / 01期
关键词
D O I
10.1093/gerona/56.1.B33
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Clinical and experimental data suggest that exercise training (ET) and food restriction (FR) improve cardiovascular function. However, the effects of long-term FR or FR in combination with ET on the recovery of cardiac function following ischemia have not been determined. Male Wistar rats were assigned to ad libitum-fed, FR, ad libitum-exercise, and FR-exercise groups. Mechanical function of isolated working hearts was assessed in response to increases in afterload resistance and following global no-flow ischemia, At low workload, there was a significant FB effect on aortic flow as well as an interaction between FR and ET on systolic pressure. These effects remained when hearts were subjected to increases in aortic afterload resistance, During reperfusion of ischemic hearts, there was a significant FR effect on aortic flow and systolic pressure and a significant ET effect on diastolic pressure. An interaction between FR and ET on heart rate was also seen during reperfusion, In terms of percent recovery of heart function following ischemia, FR continued to affect aortic now, and we observed an interaction between FR and ET on aortic flow. Our results clearly indicate that the myocardium from the FR animal or the FR, exercise-trained rat is more resistant to ischemia.
引用
收藏
页码:B33 / B37
页数:5
相关论文
共 33 条
[1]   DEMONSTRATION OF FREE-RADICAL GENERATION IN STUNNED MYOCARDIUM OF INTACT DOGS WITH THE USE OF THE SPIN TRAP ALPHA-PHENYL N-TERT-BUTYL NITRONE [J].
BOLLI, R ;
PATEL, BS ;
JEROUDI, MO ;
LAI, EK ;
MCCAY, PB .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 82 (02) :476-485
[2]   BENEFICIAL EFFECT OF CARNITINE ON MECHANICAL RECOVERY OF RAT HEARTS REPERFUSED AFTER A TRANSIENT PERIOD OF GLOBAL-ISCHEMIA IS ACCOMPANIED BY A STIMULATION OF GLUCOSE-OXIDATION [J].
BRODERICK, TL ;
QUINNEY, HA ;
BARKER, CC ;
LOPASCHUK, GD .
CIRCULATION, 1993, 87 (03) :972-981
[3]   EFFECT OF EXERCISE TRAINING AND SUCROSE FEEDING ON INSULIN-STIMULATED GLUCOSE-UPTAKE IN RATS WITH STREPTOZOTOCIN-INDUCED INSULIN-DEFICIENT DIABETES [J].
DALLAGLIO, E ;
CHANG, F ;
CHANG, H ;
WRIGHT, D ;
REAVEN, GM .
DIABETES, 1983, 32 (02) :165-168
[4]   FOOD RESTRICTION-INDUCED TRANSFORMATIONS IN CARDIAC FUNCTIONAL AND BIOCHEMICAL-PROPERTIES IN RATS [J].
HADDAD, F ;
BODELL, PW ;
MCCUE, SA ;
HERRICK, RE ;
BALDWIN, KM .
JOURNAL OF APPLIED PHYSIOLOGY, 1993, 74 (02) :606-612
[5]   EXERCISE TRAINING ATTENUATES THE REDUCTION IN MYOCARDIAL GLUT-4 IN DIABETIC RATS [J].
HALL, JL ;
SEXTON, WL ;
STANLEY, WC .
JOURNAL OF APPLIED PHYSIOLOGY, 1995, 78 (01) :76-81
[6]   DEPRESSED INVIVO MYOCARDIAL REACTIVITY TO DOBUTAMINE IN STREPTOZOTOCIN DIABETIC RATS - INFLUENCE OF EXERCISE TRAINING [J].
HELLER, BA ;
PAULSON, DJ ;
KOPP, SJ ;
PEACE, DG ;
TOW, JP .
CARDIOVASCULAR RESEARCH, 1988, 22 (06) :417-424
[7]  
HEYLIGER CE, 1985, SCIENCE, V35, P1174
[8]  
KELLEY GR, 1988, MECH AGEING DEV, V103, P1
[9]   EFFECT OF FOOD RESTRICTION ON THE PHOSPHOCREATINE ENERGY SHUTTLE COMPONENTS IN RAT-HEART [J].
KIRSCH, A ;
SAVABI, F .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1992, 24 (08) :821-830
[10]   Effect of long-term food restriction on cardiac mechanics [J].
Klebanov, S ;
Herlihy, JT ;
Freeman, GL .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1997, 273 (05) :H2333-H2342