Menopausal Hormone Therapy and Risk of Endometrial Carcinoma Among Postmenopausal Women in the European Prospective Investigation into Cancer and Nutrition

被引：95

作者：

Allen, Naomi E. ^{[1
]}

Tsilidis, Konstantinos K. ^{[1
]}

Key, Timothy J. ^{[1
]}

Dossus, Laure ^{[2
]}

Kaaks, Rudolf ^{[2
]}

Lund, Eiliv ^{[3
]}

Bakken, Kjersti ^{[3
]}

Gavrilyuk, Oxana ^{[3
]}

Overvad, Kim ^{[4
]}

Tjonneland, Anne ^{[5
]}

Olsen, Anja ^{[5
]}

Fournier, Agnes ^{[6
]}

Fabre, Alban ^{[6
]}

Clavel-Chapelon, Francoise ^{[6
]}

Chabbert-Buffet, Nathalie

Sacerdote, Carlotta ^{[9
]}

Krogh, Vittorio ^{[10
]}

Bendinelli, Benedetta ^{[11
]}

Tumino, Rosario ^{[12
]}

Panico, Salvatore ^{[13
]}

Bergmann, Manuela ^{[14
]}

Schuetze, Madlen ^{[14
]}

van Duijnhoven, Fraenzel J. B. ^{[15
]}

Bueno-de-Mesquita, H. Bas ^{[15
]}

Onland-Moret, N. Charlotte ^{[7
,8
,16
,17
]}

van Gils, Carla H. ^{[16
]}

Amiano, Pilar ^{[18
,22
]}

Barricarte, Aurelio ^{[19
,22
]}

Chirlaque, Maria-Dolores ^{[20
,22
]}

Molina-Montes, Maria-Esther ^{[21
,22
]}

Redondo, Maria-Luisa ^{[23
]}

Duell, Eric J. ^{[24
]}

Khaw, Kay-Tee ^{[25
]}

Wareham, Nick ^{[26
]}

Rinaldi, Sabina ^{[27
]}

Fedirko, Veronika ^{[27
]}

Mouw, Traci ^{[28
]}

Michaud, Dominique S. ^{[28
]}

Riboli, Elio ^{[28
]}

机构：

[1] Univ Oxford, Canc Epidemiol Unit, Nuffield Dept Clin Med, Div Med Sci, Oxford OX3 7LF, England

[2] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[3] Univ Tromso, Inst Community Med, Tromso, Norway

[4] Aarhus Univ, Dept Epidemiol, Sch Publ Hlth, Aarhus, Denmark

[5] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[6] Inst Natl Sante & Rech Med, Unite 1018, Villejuif, France

[7] Hop Tenon, Obstet Gynecol & Reprod Med Unit, F-75970 Paris, France

[8] Univ Paris 06, Dept Human Reprod Genet & Therapy, Paris, France

[9] Ctr Prevenz Oncol Piemonte, Dept Biomed Sci & Human Oncol, Turin, Italy

[10] Fdn IRCCS Ist Nazl Tumori, Nutrit Epidemiol Unit, Dept Prevent & Predict Med, Milan, Italy

[11] Canc Res & Prevent Inst, Mol & Nutrit Epidemiol Unit, Florence, Italy

[12] Civile MP Arezzo Hosp, Canc Registry & Histopathol Unit, Ragusa, Italy

[13] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[14] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[15] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[16] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[17] Univ Med Ctr Utrecht, Div Biomed Genet, Dept Med Genet, Complex Genet Sect, Utrecht, Netherlands

[18] Basque Govt, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[19] Publ Hlth Inst Navarra, Pamplona, Spain

[20] Murcia Reg Hlth Author, Dept Epidemiol, Murcia, Spain

[21] Andalusian Sch Publ Hlth, Granada, Spain

[22] CIBER Epidemiol & Salud Publ, Barcelona, Spain

[23] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[24] Catalan Inst Oncol, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[25] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[26] MRC Epidemiol Unit, Cambridge, England

[27] Int Agcy Res Canc, F-69372 Lyon, France

[28] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Epidemiol & Publ Hlth, London, England

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2010年 / 172卷 / 12期

基金：

英国医学研究理事会; 英国惠康基金; 欧洲研究理事会;

关键词：

endometrial neoplasms; estrogen replacement therapy; norpregnenes; postmenopause; prospective studies; ESTROGEN PLUS PROGESTIN; REPLACEMENT THERAPY; BREAST-CANCER; HEALTH; COHORT; TIBOLONE; ESTRADIOL; UK;

D O I：

10.1093/aje/kwq300

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

Estrogen-only menopausal hormone therapy (HT) increases the risk of endometrial cancer, but less is known about the association with other types of HT. Using Cox proportional hazards regression, the authors examined the association of various types of HT with the risk of endometrial cancer among 115,474 postmenopausal women recruited into the European Prospective Investigation into Cancer and Nutrition between 1992 and 2000. After a mean follow-up period of 9 years, 601 incident cases of endometrial cancer were identified. In comparison with never users of HT, risk of endometrial cancer was increased among current users of estrogen-only HT (hazard ratio (HR) = 2.52, 95% confidence interval (CI): 1.77, 3.57), tibolone (HR = 2.96, 95% CI: 1.67, 5.26), and, to a lesser extent, estrogen-plus-progestin HT (HR = 1.41, 95% CI: 1.08, 1.83), although risks differed according to regimen and type of progestin constituent. The association of HT use with risk was stronger among women who were older, leaner, or had ever smoked cigarettes. The finding of a strong increased risk of endometrial cancer with estrogen-only HT and a weaker association with combined HT supports the hypothesis that progestins have an attenuating effect on endometrial cancer risk. The increased risk associated with tibolone use requires further investigation.

引用

页码：1394 / 1403

页数：10

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