Exploration of the awakening cortisol response in relation to diurnal cortisol secretory activity

被引:276
作者
Edwards, S
Clow, A
Evans, P
Hucklebridge, F
机构
[1] Univ Westminster, Dept Biomed Sci, London W1M 8JS, England
[2] Univ Westminster, Dept Psychol, Psychophysiol & Stress Res Grp, London W1M 8JS, England
关键词
salivary free cortisol; diurnal cycle; cortisol status;
D O I
10.1016/S0024-3205(01)00996-1
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Adrenocortical activity can be assessed by measurement of free cortisol in saliva. Cortisol status has important health implications in both physical and psychological terms, Assessment of cortisol status is complicated by the marked diurnal cortisol cycle. This cycle is characterised by an increase in secretory activity following awakening to achieve the morning acrophase. Thereafter it falls with a declining trend over the remainder of the day, For between subject studies the timing of sampling in relation to this cycle is an important consideration. We report a comprehensive study of the diurnal free cortisol cycle designed to analyse its components and to investigate their reliability and inter-relatedness. We instructed 42 healthy volunteers to collect saliva samples at home on two consecutive days. On each day the first sample was collected immediately upon awakening, followed by a further three samples at 15-minute intervals which collectively comprised the "awakening samples". A further four samples were collected through the day at 3-hour intervals, all synchronized to awakening time. The cortisol response to awakening was calculated in two ways. Overall cortisol production in the first 45 minutes after awakening was calculated as area under the cortisol curve with reference to zero (AUC). The dynamic of the cortisol response to awakening was calculated as area under the cortisol response curve (AURC) with reference to the first awakening sample. In addition the underlying cortisol secretory activity was assessed based upon the diurnal three-hourly samples. All three parameters of adrenocortical activity showed reasonable stability across the two sampling days indicating all were reliable indexes of trait characteristic. AUC was representative of underlying diurnal activity but AURC was not. Measurement at any time point, 3, 6, 9 or 12 hours post-awakening was representative of the underlying 12-hour diurnal activity, (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:2093 / 2103
页数:11
相关论文
共 22 条
[1]  
Aardal E, 1995, EUR J CLIN CHEM CLIN, V33, P927
[2]   Salivary cortisol - an alternative to serum cortisol determinations in dynamic function tests [J].
Aardal-Eriksson, E ;
Karlberg, BE ;
Holm, AC .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 1998, 36 (04) :215-222
[3]   Timing the end of nocturnal sleep [J].
Born, J ;
Hansen, K ;
Marshall, L ;
Mölle, M ;
Fehm, HL .
NATURE, 1999, 397 (6714) :29-30
[4]   Hypothalamus-pituitary-adrenal activity during human sleep: A coordinating role for the limbic hippocampal system [J].
Born, J ;
Fehm, HL .
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 1998, 106 (03) :153-163
[5]   Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway [J].
Buijs, RM ;
Wortel, J ;
van Heerikhuize, JJ ;
Feenstra, MGP ;
Ter Horst, GJ ;
Romijn, HJ ;
Kalsbeek, A .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (05) :1535-1544
[6]   RELIABILITY OF HORMONAL LEVELS FOR ASSESSING THE HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL SYSTEM IN CLINICAL-PHARMACOLOGY [J].
COSTE, J ;
STRAUCH, G ;
LETRAIT, M ;
BERTAGNA, X .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1994, 38 (05) :474-479
[7]  
EVANS P, 2000, MIND IMMUNITY HLTH S
[8]   The cortisol response to normal and nocturnal awakening [J].
Hucklebridge, F ;
Clow, A ;
Rahman, H ;
Evans, P .
JOURNAL OF PSYCHOPHYSIOLOGY, 2000, 14 (01) :24-28
[9]   The awakening cortisol response and blood glucose levels [J].
Hucklebridge, FH ;
Clow, A ;
Abeyguneratne, T ;
Huezo-Diaz, P ;
Evans, P .
LIFE SCIENCES, 1999, 64 (11) :931-937
[10]   SALIVARY CORTISOL IN PSYCHONEUROENDOCRINE RESEARCH - RECENT DEVELOPMENTS AND APPLICATIONS [J].
KIRSCHBAUM, C ;
HELLHAMMER, DH .
PSYCHONEUROENDOCRINOLOGY, 1994, 19 (04) :313-333