A follow up study of suicide attempters:: Increase of CSF-somatostatin but no change in CSF-CRH

被引:15
作者
Westrin, Å
Ekman, R
Regnéll, G
Tråskman-Bendz, L
机构
[1] Lund Univ, Dept Clin Neurosci, Div Psychiat, Lund, Sweden
[2] Univ Gothenburg, Dept Psychiat & Neurochem, Inst Clin Neurosci, Gothenburg, Sweden
关键词
suicide attempt; follow-up; corticotrophin-releasing hormone; somatostatin; hypothalamic-pituitary-adrenocortical axis; major depressive disorder;
D O I
10.1016/S0924-977X(01)00073-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Concentrations of somatostatin and corticotrophin releasing hormone (CRH), measured in cerebrospinal fluid (CSF) have been reported to be low in suicidal patients with major depressive disorder (MDD). Often have MDD patients in general, high CSF-CRH and low CSF-somatostatin concentrations, which both seem to normalise with clinical recovery. The present study was designed to look for CSF-CRI-I and CSF-somatostatin alterations along with clinical changes in patients studied repeatedly after a suicide attempt. Sixteen patients with different diagnoses, initially inpatients after a suicide attempt (baseline), participated. Lumbar punctures and ratings according to the Suicidal Assessment Scale (SUAS) and the Montgomery-Asberg Depression Rating Scale (MADRS) were performed while patients were drug-frre (baseline) anti after a median of 7 (5 to 9) months. At follow up MADRS- and SUAS-scores were significantly decreased (P<0.05), whereas CSF-somatostatin was significantly increased (P=0.013) and CSF-CRH had not changed significantly. Thus, the patients showed long-lasting low CSF-CRH concentrations, in spite of changed CSF-somatostatin concentrations and clinical amelioration. <(c)> 2001 Elsevier Science B,V. All rights reserved.
引用
收藏
页码:135 / 143
页数:9
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