NACP-REP1 polymorphism is not involved in Parkinson's disease: a case control study in a population sample from southern Italy

被引：38

作者：

Spadafora, P

Annesi, G

Pasqua, AA

Serra, P

Candiano, ICC

Carrideo, S

Tarantino, P

Civitelli, D

De Marco, EV

Nicoletti, G

Annesi, F

Quattrone, A

机构：

[1] CNR, Inst Neurol Sci, Cosenza, Italy

[2] Magna Graecia Univ Catanzaro, Fac Med & Chirurg, Inst Neurol, Policlin MaterDomini, I-88100 Catanzaro, Italy

来源：

NEUROSCIENCE LETTERS | 2003年 / 351卷 / 02期

关键词：

Parkinson's disease (PD); NACP-REP1; polymorphism; alpha-synuclein (SNCA);

D O I：

10.1016/S0304-3940(03)00859-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Contradictory evidence has been reported on the role of the polymorphic mixed dinucleotide repeat (NACP-REP I) of the alpha-synuclein gene as a risk factor for sporadic Parkinson's disease (PD). In the present study we genotyped the NACP-REPI polymorphism in 189 PD patients from southern Italy and 182 healthy control subjects. We failed to demonstrate an association of any NACP-REPI allele with PD. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

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页码：75 / 78

页数：4

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