Spatial memory impairment in OLETF rats without cholecystokinin - a receptor

被引：21

作者：

Matsushita, H ^{[1
]}

Akiyoshi, J ^{[1
]}

Kai, K ^{[1
]}

Ishii, N ^{[1
]}

Kodama, K ^{[1
]}

Tsutsumi, T ^{[1
]}

Isogawa, K ^{[1
]}

Nagayama, H ^{[1
]}

机构：

[1] Oita Med Univ, Dept Neuropsychiat, Oita 8795593, Japan

来源：

NEUROPEPTIDES | 2003年 / 37卷 / 05期

关键词：

CCK-A-receptor; behavior; cholecystokinin; memory; learning; passive avoidance; water maze;

D O I：

10.1016/s0143-4179(03)00083-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cholecystokinin (CCK) is one of the most abundant neurotransmitter peptides in the brain. As Otsuka Long-Evans Tokushima Fatty (OLETF) rats lack CCK-A receptor because of a genetic abnormality, we examined whether learning and memory were impaired in these animals using both Morris water maze (MWM) and step-through type passive avoidance (PA) learning test. In the MWM test, memory impairment was observed in OLETF rats. The number of errors was also significantly higher, and that of the correct choices was significantly lower in OLETF rats compared to the controls [Long-Evans Tokushima Otsuka (LETO)] rats. In PA, OLETF rats did not show facilitating response 24 It after training. From these observations, we concluded that a spatial memory was impaired in the OLETF rats. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：271 / 276

页数：6

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