Structure and properties of iron oxide nanoparticles encapsulated by phospholipids with poly(ethylene glycol) tails

被引:63
作者
Shtykova, Eleonora V.
Huang, Xinlei
Remmes, Nicholas
Baxter, David
Stein, Barry
Dragnea, Bogdan
Svergun, Dmitri I.
Bronstein, Lyudmila M.
机构
[1] Russian Acad Sci, Inst Cristallog, Moscow 117333, Russia
[2] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA
[3] Indiana Univ, Dept Phys, Bloomington, IN 47405 USA
[4] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
[5] European Mol Biol Lab, Hamburg Outstn, D-22603 Hamburg, Germany
关键词
D O I
10.1021/jp075235c
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Iron oxide nanoparticles with diameters of 20.1 and 8.5 nm coated with phospholipids containing poly(ethylene glycol) (PEG) tails were studied using small-angle X-ray scattering (SAXS), transmission electron microscopy, dynamic light scattering, and magnetometry. Novel SAXS data analysis methods are applied to build three-dimensional structural models of the nanciparticles coated with PEGylated phospholipids in aqueous solution. The SAXS data demonstrate that the density inside iron oxide nanoparticles is not uniform and depends on the nanoparticle size, which in turn is dependent on the reaction conditions. This heterogeneity is attributed to the presence of two crystalline phases, spinel and wustite, in the nanoparticles. Because of magnetic properties, the nanoparticles in solution associate in flexible dynamic clusters consisting on average Of four individual cores. The magnetometry further supports the SAXS-based models.
引用
收藏
页码:18078 / 18086
页数:9
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