High-resolution imaging of the supercritical antisolvent process

被引：7

作者：

Bell, PW ^{[1
]}

Stephens, AP ^{[1
]}

Roberts, CB ^{[1
]}

Duke, SR ^{[1
]}

机构：

[1] Auburn Univ, Dept Chem Engn, Auburn, AL 36849 USA

来源：

EXPERIMENTS IN FLUIDS | 2005年 / 38卷 / 06期

关键词：

D O I：

10.1007/s00348-005-0933-4

中图分类号：

TH [机械、仪表工业];

学科分类号：

0802 ;

摘要：

A high-magnification and high-resolution imaging technique was developed for the supercritical fluid antisolvent (SAS) precipitation process. Visualizations of the jet injection, flow patterns, droplets, and particles were obtained in a high-pressure vessel for polylactic acid and budesonide precipitation in supercritical CO2. The results show two regimes for particle production: one where turbulent mixing occurs in gas-like plumes, and another where distinct droplets were observed in the injection. Images are presented to demonstrate the capabilities of the method for examining particle formation theories and for understanding the underlying fluid mechanics, thermodynamics, and mass transport in the SAS process.

引用

页码：708 / 719

页数：12

共 33 条

[1]

[Anonymous], 2000, Science and Engineering of Droplets

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