When two strands are better than one: The mediators and modulators of the cellular responses to double-stranded RNA

被引：512

作者：

Jacobs, BL ^{[1
]}

Langland, JO ^{[1
]}

机构：

[1] ARIZONA STATE UNIV, GRAD PROGRAM MOL & CELLULAR BIOL, TEMPE, AZ 85287 USA

来源：

VIROLOGY | 1996年 / 219卷 / 02期

关键词：

DEPENDENT PROTEIN-KINASE; HUMAN-IMMUNODEFICIENCY-VIRUS; INITIATION FACTOR-II; EPSTEIN-BARR-VIRUS; ADENOVIRUS VAI RNA; TREATED HELA-CELLS; 67-KDA POLYPEPTIDE P67; VACCINIA VIRUS; INTERFERON ACTION; 2-5A SYNTHETASE;

D O I：

10.1006/viro.1996.0259

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Double-stranded RNA is a potent inducer of interferon, a modulator of the expression of a number of other genes involved in the response of cells to virus infection, an activator of the interferon-induced antiviral state, and may be involved in differentiation, induction of apoptosis, and control of oncogenic transformation. This review will attempt to summarize what is known about the cellular proteins that act to mediate the response of cells to double-stranded RNA and the viral and cellular macromolecules that may be able to modulate these responses. (C) 1996 Academic Press, Inc.

引用

页码：339 / 349

页数：11

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