Carbachol, an acetylcholine receptor agonist, enhances production in rat aorta of 2-arachidonoyl glycerol, a hypotensive endocannabinoid

被引：90

作者：

Mechoulam, R ^{[1
]}

Fride, E

Ben-Shabat, S

Meiri, U

Horowitz, M

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Fac Med, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Div Physiol, Fac Dent, IL-91120 Jerusalem, Israel

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 362卷 / 01期

关键词：

hypotension; 2-arachidonoyl glycerol; cannabinoid;

D O I：

10.1016/S0014-2999(98)00777-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The production of 2-arachidonoyl glycerol, an endogenous cannabinoid, is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with carbachol, an acetylcholine receptor agonist. 2-Arachidonoyl glycerol potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：R1 / R3

页数：3

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