The correlation between cotransplantation of mesenchymal stem cells and higher recurrence rate in hematologic malignancy patients: outcome of a pilot clinical study

被引：280

作者：

Ning, H. ^{[1
]}

Yang, F. ^{[1
]}

Jiang, M. ^{[1
]}

Hu, L. ^{[1
]}

Feng, K. ^{[1
]}

Zhang, J. ^{[1
]}

Yu, Z. ^{[1
]}

Li, B. ^{[1
]}

Xu, C. ^{[1
]}

Li, Y. ^{[1
]}

Wang, J. ^{[1
]}

Hu, J. ^{[1
]}

Lou, X. ^{[1
]}

Chen, H. ^{[1
]}

机构：

[1] Affiliated Hosp Acad Mil Med Sci, Dept Hematopoiet Stem Cell Transplantat, Beijing 100071, Peoples R China

来源：

LEUKEMIA | 2008年 / 22卷 / 03期

关键词：

mesenchymal stem cells; hematopoietic stem cell transplantation; graft-versus-host disease; graft versus leukemia;

D O I：

10.1038/sj.leu.2405090

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this open-label randomized clinical trial, HLA-identical sibling-matched hematopoietic stem cells (HSC) were transplanted (non-MSCs group, n = 15) or cotransplanted with mesenchymal stem cells (MSCs) (MSCs group, n = 10) in hematologic malignancy patients. The median number of MSCs infused was 3.4 x 10(5) kg(-1) (range, 0.3-15.3 x 10(5) kg(-1)). MSCs infusions were well tolerated. The median time to neutrophil engraftment (absolute neutrophil count >0.5 x 10(9) l(-1)) was 16 days for MSCs group and 15 days for non-MSCs group. The median time to platelet engraftment (platelet count >50 x 10(9) l(-1)) was 30 and 27 days, respectively. Grades II-IV acute graft-versus-host disease (GVHD) was observed respectively, in one (11.1%) and eight (53.3%) evaluable patients. Chronic GVHD was found in one (14.3%) and four (28.6%) evaluable patients. The number of patients who relapsed were six (60.0%) and three (20.0%), and the 3-year disease-free survivals were 30.0 and 66.7%, respectively. Thus cotransplantation of MSCs and HSCs may prevent GVHD, but the relapse rate is obviously higher than the control group. We conclude that use of MSCs must be handled with extreme caution before a large-scale clinical trial is performed.

引用

页码：593 / 599

页数：7

共 41 条

[1] Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice [J].