Regulation of cell migration by the C2 domain of the tumor suppressor PTEN

被引:269
作者
Raftopoulou, M
Etienne-Manneville, S
Self, A
Nicholls, S
Hall, A
机构
[1] UCL, MRC, Mol Cell Biol Lab, London WC1E 6BT, England
[2] UCL, Cell Biol Unit, Canc Res UK Oncogene & Signal Transduct Grp, London WC1E 6BT, England
[3] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
关键词
D O I
10.1126/science.1092089
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
PTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway. We show here that PTEN can also inhibit cell migration through its C2 domain, independent of its lipid phosphatase activity. This activity depends on the protein phosphatase activity of PTEN and on dephosphorylation at a single residue, threonine(383). The ability of PTEN to control cell migration through its C2 domain is likely to be an important feature of its tumor suppressor activity.
引用
收藏
页码:1179 / 1181
页数:3
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