Potential role of the mannose receptor in antigen transport

被引：27

作者：

Martínez-Pomares, L ^{[1
]}

Gordon, S ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

IMMUNOLOGY LETTERS | 1999年 / 65卷 / 1-2期

关键词：

mannose receptor; mouse; secondary lymphoid organs; macrophages; antigen presentation;

D O I：

10.1016/S0165-2478(98)00117-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in follicular dendritic cells and migratory dendritic cells in immunised animals. Based on this labelling pattern and the identification of a soluble form of the MR in macrophage-conditioned media and mouse serum, we propose a novel role for this receptor in antigen transport. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：9 / 13

页数：5

共 26 条

[1] THE HUMAN 180-KDA RECEPTOR FOR SECRETORY PHOSPHOLIPASES A(2) - MOLECULAR-CLONING, IDENTIFICATION OF A SECRETED SOLUBLE FORM, EXPRESSION, AND LOCALIZATION [J].

ANCIAN, P ;

LAMBEAU, G ;

MATTEI, MG ;

LAZDUNSKI, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (15) :8963-8970

[2] PURIFICATION AND PROPERTIES OF SIALOADHESIN, A SIALIC ACID-BINDING RECEPTOR OF MURINE TISSUE MACROPHAGES [J].

CROCKER, PR ;

KELM, S ;

DUBOIS, C ;

MARTIN, B ;

MCWILLIAM, AS ;

SHOTTON, DM ;

PAULSON, JC ;

GORDON, S .

EMBO JOURNAL, 1991, 10 (07) :1661-1669

[3] SIALOADHESIN, A MACROPHAGE SIALIC-ACID BINDING-RECEPTOR FOR HEMATOPOIETIC-CELLS WITH 17 IMMUNOGLOBULIN-LIKE DOMAINS [J].

CROCKER, PR ;

MUCKLOW, S ;

BOUCKSON, V ;

MCWILLIAM, A ;

WILLIS, AC ;

GORDON, S ;

MILON, G ;

KELM, S ;

BRADFIELD, P .

EMBO JOURNAL, 1994, 13 (19) :4490-4503

[4] The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells [J].

Engering, AJ ;

Cella, M ;

Fluitsma, D ;

Brockhaus, M ;

Hoefsmit, ECM ;

Lanzavecchia, A ;

Pieters, J .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (09) :2417-2425

[5] MOLECULAR CHARACTERIZATION OF THE HUMAN MACROPHAGE MANNOSE RECEPTOR - DEMONSTRATION OF MULTIPLE CARBOHYDRATE RECOGNITION-LIKE DOMAINS AND PHAGOCYTOSIS OF YEASTS IN COS-1 CELLS [J].

EZEKOWITZ, RAB ;

SASTRY, K ;

BAILLY, P ;

WARNER, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (06) :1785-1794

[6] Isolation of the SO4-4-GalNAc beta 1,4GlcNAc beta 1,2Man alpha-specific receptor from rat liver [J].

Fiete, D ;

Baenziger, JU .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (23) :14629-14637

[7]

HARRIS N, 1992, BLOOD, V80, P2363

[8]

ISHIZAKI J, 1994, J BIOL CHEM, V269, P5897

[9] THE RECEPTOR DEC-205 EXPRESSED BY DENDRITIC CELLS AND THYMIC EPITHELIAL-CELLS IS INVOLVED IN ANTIGEN-PROCESSING [J].

JIANG, WP ;

SWIGGARD, WJ ;

HEUFLER, C ;

PENG, M ;

MIRZA, A ;

STEINMAN, RM ;

NUSSENZWEIG, MC .

NATURE, 1995, 375 (6527) :151-155

[10] cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells [J].

Kato, M ;

Neil, TK ;

Clark, GJ ;

Morris, CM ;

Sorg, RV ;

Hart, DNJ .

IMMUNOGENETICS, 1998, 47 (06) :442-450

← 1 2 3 →