Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population

被引：50

作者：

Blanton, Ronald E. ^{[1
]}

Silva, Luciano K. ^{[2
]}

Morato, Vanessa G. ^{[3
]}

Parrado, Antonio R. ^{[4
]}

Dias, Juarez P. ^{[5
]}

Melo, Paulo R. S. ^{[2
]}

Reis, Eliana A. G. ^{[2
]}

Goddard, Katrina A. B. ^{[4
]}

Nunes, Marcio R. T. ^{[6
]}

Rodrigues, Sueli G. ^{[6
]}

Vasconcelos, Pedro F. C. ^{[6
]}

Castro, Jesuina M.

Reis, Mitermayer G. ^{[2
]}

Barreto, Mauricio L. ^{[3
]}

Teixeira, M. Gloria ^{[3
]}

机构：

[1] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA

[2] Ctr Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Lab Pathol & Mol Biol, Salvador, BA, Brazil

[3] Univ Fed Bahia, Inst Collect Hlth, Salvador, BA, Brazil

[4] Case Western Reserve Univ, Div Genet Epidemiol, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

[5] CAB Int, Secretaria Saude Estado Bahia, Salvador, BA, Brazil

[6] Inst Evandro Chagas, Dept Arbovirol & Hemorrhag Fever, Belem, Para, Brazil

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2008年 / 16卷 / 06期

关键词：

ethnicity; race; population structure; socioeconomic status; DENV3;

D O I：

10.1038/ejhg.2008.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever (DHF) as well as 293 neighborhood cases of dengue fever and 294 asymptomatic controls in Salvador, Bahia, Brazil. Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income, both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P = 0.02, OR = 0.28 and P = 0.02, OR = 0.13, respectively). Income or an index of income indicators, however, was also independently associated with the diagnosis of DHF.

引用

页码：762 / 765

页数：4

共 15 条

[1] Health inequalities based on ethnicity in individuals aged 15 to 64, Brazil, 1998 [J].

Barata, Rita Barradas ;

de Almeida, Marcia Furquim ;

Montero, Claudia Valencia ;

da Silva, Zilda Pereira .

CADERNOS DE SAUDE PUBLICA, 2007, 23 (02) :305-313

[2]

Brown T. U., 2004, Dengue Bulletin, V28, P7

[3] Dengue and dengue hemorrhagic fever [J].

Gubler, DJ .

CLINICAL MICROBIOLOGY REVIEWS, 1998, 11 (03) :480-+

[4] Stabilizer orbit of Virasoro action and integrable systems [J].

Guha, P .

INTERNATIONAL JOURNAL OF GEOMETRIC METHODS IN MODERN PHYSICS, 2005, 2 (01) :1-12

[5] Haiti: Absence of dengue hemorrhagic fever despite hyperendemic dengue virus transmission [J].

Halstead, SB ;

Streit, TG ;

Lafontant, JG ;

Putvatana, R ;

Russell, K ;

Sun, W ;

Kanesa-Thasan, N ;

Hayes, CG ;

Watts, DM .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2001, 65 (03) :180-183

[6]

Hung NT, 2005, AM J TROP MED HYG, V72, P370

[7] Implications of correlations between skin color and genetic ancestry for biomedical research [J].

Parra, EJ ;

Kittles, RA ;

Shriver, MD .

NATURE GENETICS, 2004, 36 (11) :S54-S60

[8]

Pritchard JK, 2000, GENETICS, V155, P945

[9] DISTRUCT: a program for the graphical display of population structure [J].

Rosenberg, NA .

MOLECULAR ECOLOGY NOTES, 2004, 4 (01) :137-138

[10] A variant in the CD209 promoter is associated with severity of dengue disease [J].

Sakuntabhai, A ;

Turbpaiboon, C ;

Casadémont, I ;

Chuansumrit, A ;

Lowhnoo, T ;

Kajaste-Rudnitski, A ;

Kalayanarooj, SM ;

Tangnararatchakit, K ;

Tangthawornchaikul, N ;

Vasanawathana, S ;

Chaiyaratana, W ;

Yenchitsomanus, PT ;

Suriyaphol, P ;

Avirutnan, P ;

Chokephaibulkit, K ;

Matsuda, F ;

Yoksan, S ;

Jacob, Y ;

Lathrop, GM ;

Malasit, P ;

Desprès, P ;

Julier, C .

NATURE GENETICS, 2005, 37 (05) :507-513

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