Nε-(carboxymethyl)lysine during the early development of hypertension

被引：22

作者：

Baumann, Marcus ^{[1
,2
]}

Stehouwer, Coen ^{[3
]}

Scheijen, Jean ^{[3
]}

Heemann, Uwe ^{[1
]}

Boudier, Harry Struijker ^{[2
]}

Schalkwijk, Casper ^{[3
]}

机构：

[1] Tech Univ Munich, Dept Nephrol, Klinikum Rechts Isar, D-81675 Munich, Germany

[2] Univ Maastricht, Dept Pharmacol & Toxicol, Maastricht, Netherlands

[3] Univ Hosp Maastricht, Dept Internal Med, Div Gen Internal Med, Maastricht, Netherlands

来源：

MAILLARD REACTION: RECENT ADVANCES IN FOOD AND BIOMEDICAL SCIENCES | 2008年 / 1126卷

关键词：

N-epsilon-(carboxymethyl)lysine; hypertension; spontaneously hypertensive rat; renal function; oxidative stress;

D O I：

10.1196/annals.1433.004

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Advanced glycation end products (AGEs) are associated with hypertension. Whether N-epsilon-(carhoxymethyl)lysine (CML) contributes to the development of hypertension in young spontaneously hypertensive rats (SHR) remains to be established compared to W. We determined blood pressure, renal function, marker for oxidative stress (OS), and CML in young WKY rats and SHR. We found blood pressure was increased in SHR with no difference in renal function and OS compared to WKY. CML was elevated in plasma (2.3 +/- 0.3 vs. 1.3 +/- 0.2 mu mol/L) and kidney (1.0 +/- 0. 1 vs. 0.5 +/- 0.1 mu mol/L) compared to WKY. Early CML accumulation may contribute to the development of hypertension potentially by inducing early renal inflammation independent of glomerular dysfunction or oxidative stress.

引用

页码：201 / 204

页数：4

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