The incidence of rheumatoid arthritis in Spain: results from a nationwide primary care registry

被引:81
作者
Carbonell, J. [1 ]
Cobo, T. [2 ]
Balsa, A. [2 ]
Descalzo, M. A. [3 ]
Carmona, L. [3 ]
机构
[1] Hosp Mar, Inst Municipal Atencio Sanitaria, Dept Rheumatol, Barcelona, Spain
[2] Hosp La Paz, Dept Rheumatol, Madrid, Spain
[3] Fdn Espanola Reumatol, Res Unit, Madrid, Spain
关键词
incidence; arthritis; rheumatoid; population studies; epidemiology; early diagnosis; primary care; registries; cohort studies; disease occurrence;
D O I
10.1093/rheumatology/ken205
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To estimate the incidence of early arthritis (EA) and of RA in adults (> 16 yrs) in Spain. Methods. Primary care physicians were instructed in the detection of new cases using a checklist. All cases were evaluated at EA units (EAUs) within 15 days of detection. ACR criteria for the classification of RA were assessed every 6 months thereafter. Results. In an area covering 4 342 378 inhabitants over the age of 16 yrs, 2467 patients were referred to the EAU, of whom 1063 fulfilled EA criteria (43.1%). After 6 months, 362 patients fulfilled RA criteria. The estimated annual incidence of EA was 25/100 000 population (95% CI: 23, 26). The annual incidence of RA was 8.3 cases/100 000 (95% CI: 7.5, 9.2): 11.3/100 000 in women (95% CI: 10.0, 12.8), and 5.2/100 000 in men (95% CI: 4.3, 6.3). The incidence of RA increased with age in both sexes. At the 6 months' assessment, 187 (51.7%) of the patients with RA were RF positive. The presentation of RA was mainly polyarticular (n = 268; 74.0%). There were 701/1063 patients with EA who did not fulfil RA criteria by 6 months after the first rheumatologist visit. If all cases of undifferentiated arthritis (n = 118; 17%) became RA, the incidence would be in the range of 10 cases/100 000 population. Conclusions. RA incidence in Spain is in the lower range of published data. The incidence of EA is about three times that of RA.
引用
收藏
页码:1088 / 1092
页数:5
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