High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome

被引：162

作者：

Kasprowicz, Victoria ^{[1
]}

Wiesch, Julian Schulze zur ^{[1
,2
,11
]}

Kuntzen, Thomas ^{[1
]}

Nolan, Brian E. ^{[1
]}

Longworth, Steven ^{[1
]}

Berical, Andrew ^{[1
]}

Blum, Jenna ^{[1
]}

McMahon, Cory ^{[1
]}

Reyor, Laura L. ^{[1
]}

Elias, Nahel ^{[1
,3
,11
]}

Kwok, William W. ^{[4
]}

McGovern, Barbara G. ^{[5
,6
]}

Freeman, Gordon ^{[7
]}

Chung, Raymond T. ^{[8
,11
]}

Klenerman, Paul ^{[9
]}

Lewis-Ximenez, Lia ^{[10
]}

Walker, Bruce D. ^{[1
,11
]}

Allen, Todd M. ^{[1
]}

Kim, Arthur Y. ^{[1
]}

Lauer, Georg M. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02129 USA

[2] Univ Hamburg, Med Klin 1, Hamburg, Germany

[3] Massachusetts Gen Hosp, Dept Surg, Transplantat Unit, Boston, MA 02114 USA

[4] Benaroya Res Inst Virginia Mason, Seattle, WA USA

[5] Lemuel Shattuck Hosp, Boston, MA USA

[6] Tufts Univ, Sch Med, Boston, MA 02111 USA

[7] Harvard Univ, Sch Med, Dept Med, Dana Farber Canc Inst,Dept Med Oncol, Boston, MA 02115 USA

[8] Massachusetts Gen Hosp, Dept Surg, Gastrointestinal Unit, Boston, MA 02114 USA

[9] Univ Oxford, Nuffield Dept Med, Oxford OX1 3SY, England

[10] Fiocruz MS, Inst Oswaldo Cruz, Dept Virol, BR-21045900 Rio De Janeiro, Brazil

[11] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

JOURNAL OF VIROLOGY | 2008年 / 82卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.02474-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.

引用

页码：3154 / 3160

页数：7

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