Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis

被引：98

作者：

Bowes, John ^{[1
]}

Orozco, Gisela ^{[1
]}

Flynn, Edward ^{[1
]}

Ho, Pauline ^{[1
,2
]}

Brier, Rasha ^{[1
]}

Marzo-Ortega, Helena ^{[3
]}

Coates, Laura ^{[3
]}

McManus, Ross ^{[4
]}

Ryan, Anthony W. ^{[4
]}

Kane, David ^{[5
]}

Korendowych, Eleanor ^{[6
,7
]}

McHugh, Neil ^{[6
,7
]}

FitzGerald, Oliver ^{[8
,9
]}

Packham, Jonathan ^{[10
,11
]}

Morgan, Ann W. ^{[3
]}

Bruce, Ian N. ^{[1
,2
]}

Barton, Anne ^{[1
,2
]}

机构：

[1] Univ Manchester, Arthrit Res UK, Manchester Acad Hlth Sci Ctr, Epidemiol Unit, Manchester, Lancs, England

[2] Cent Manchester Fdn Trust, NIHR Manchester Biomed Res Ctr, Kellgren Ctr Rheumatol, Manchester, Lancs, England

[3] Univ Leeds, Leeds Inst Mol Med, NIHR Leeds Musculoskeletal Biomed Res Unit, Leeds, W Yorkshire, England

[4] Trinity Coll Dublin, Inst Mol Med, Dept Clin Med, Dublin, Ireland

[5] Adelaide & Meath Hosp, Dublin, Ireland

[6] Royal Natl Hosp Rheumat Dis, Bath BA1 1RL, Avon, England

[7] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

[8] St Vincents Univ Hosp, UCD Sch Med & Med Sci, Dept Rheumatol, Dublin 4, Ireland

[9] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin 2, Ireland

[10] Haywood Hosp, Stoke On Trent, Staffs, England

[11] Univ Keele, Arthrit Res UK Primary Care Ctr, Keele ST5 5BG, Staffs, England

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2011年 / 70卷 / 09期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; GENETIC-VARIANTS; POLYMORPHISMS; POPULATION; TRAF3IP2; PATHWAYS; VULGARIS; LINKAGE; DISEASE;

D O I：

10.1136/ard.2011.150102

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives To investigate a shared genetic aetiology for skin involvement in psoriasis and psoriatic arthritis (PsA) by genotyping single-nucleotide polymorphisms (SNPs), reported to be associated in genome-wide association studies of psoriasis, in patients with PsA. Methods SNPs with reported evidence for association with psoriasis were genotyped in a PsA case and control collection from the UK and Ireland. Genotype and allele frequencies were compared between PsA cases and controls using the Armitage test for trend. Results Seven SNPs mapping to the IL1RN, TNIP1, TNFAIP3, TSC1, IL23A, SMARCA4 and RNF114 genes were successfully genotyped. The IL23A and TNIP1 genes showed convincing evidence for association (rs2066808, p = 9.1 x 10(-7); rs17728338, p = 3.5 x 10(-5), respectively) whilst SNPs mapping to the TNFAIP3, TSC1 and RNF114 genes showed nominal evidence for association (rs610604, p = 0.03; rs1076160, p = 0.03; rs495337, p = 0.0025). No evidence for association with IL1RN or SMARCA4 was found but the power to detect association was low. Conclusions SNPs mapping to previously reported psoriasis loci show evidence for association to PSA, thus supporting the hypothesis that the genetic aetiology of skin involvement is the same in both PsA and psoriasis.

引用

页码：1641 / 1644

页数：4

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