Molecular mechanisms of hyperoxia-induced acute lung injury

被引：80

作者：

Bhandari, Vineet ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Pediat, Div Perinatal Med, New Haven, CT 06520 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2008年 / 13卷

关键词：

oxygen; pulmonary; cell death; apoptosis; necrosis; review;

D O I：

10.2741/3179

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Hyperoxia-induced acute lung injury (HALI) is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. Reactive oxygen species have been postulated to have a significant role in HALI, in part, by inducing cell death responses regulated by shared common mediators of apoptotic and necrotic pathways. Significant differences exist in the response of the mature and developing lung to HALI.

引用

页码：6653 / 6661

页数：9

共 116 条

[1]

Endothelial Akt activation by hyperoxia: Role in cell survival [J].

Ahmad, A ;

Ahmad, S ;

Chang, LY ;

Schaack, J ;

White, CW .

FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (07) :1108-1118

[2]

Extracellular ATP-mediated signaling for survival in Hyperoxia-induced oxidative stress [J].

Ahmad, S ;

Ahmad, A ;

Ghosh, M ;

Leslie, CC ;

White, CW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (16) :16317-16325

[3]

VASCULAR ENDOTHELIAL GROWTH-FACTOR ACTS AS A SURVIVAL FACTOR FOR NEWLY FORMED RETINAL-VESSELS AND HAS IMPLICATIONS FOR RETINOPATHY OF PREMATURITY [J].

ALON, T ;

HEMO, I ;

ITIN, A ;

PEER, J ;

STONE, J ;

KESHET, E .

NATURE MEDICINE, 1995, 1 (10) :1024-1028

[4]

Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung [J].

Asikainen, TM ;

Schneider, BK ;

Waleh, NS ;

Clyman, RI ;

Ho, WB ;

Flippin, LA ;

Günzler, V ;

White, CW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (29) :10212-10217

[5]

Blocking neutrophil influx reduces DNA damage in hyperoxia-exposed newborn rat lung [J].

Auten, RL ;

Whorton, MH ;

Mason, SN .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2002, 26 (04) :391-397

[6]

Auten RL, 2001, J PHARMACOL EXP THER, V299, P90

[7]

Mechanisms of cell injury and death in hyperoxia - Role of cytokines and Bcl-2 family proteins [J].

Barazzone, C ;

White, CW .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2000, 22 (05) :517-519

[8]

Oxygen toxicity in mouse lung: Pathways to cell death [J].

Barazzone, C ;

Horowitz, S ;

Donati, YR ;

Rodriguez, I ;

Piguet, PF .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 19 (04) :573-581

[9]

Leptin resistance protects mice from hyperoxia-induced acute lung injury [J].

Bellmeyer, Amy ;

Martino, Janice M. ;

Chandel, Navdeep S. ;

Budinger, G. R. Scott ;

Dean, David A. ;

Mutlu, Gokhan M. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 175 (06) :587-594

[10]

Bronchopulmonary dysplasia: An update [J].

Bhandari, Anita ;

Bhandari, Vineet .

INDIAN JOURNAL OF PEDIATRICS, 2007, 74 (01) :73-77

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