Metabolic assessment of the brain using proton magnetic resonance spectroscopy in a growth-restricted human fetus: Case report

被引：27

作者：

Azpurua, Humberto ^{[1
]}

Alvarado, Arturo ^{[2
]}

Mayobre, Finita ^{[3
]}

Salom, Tamara ^{[4
]}

Copel, Joshua A. ^{[1
]}

Guevara-Zuloaga, Freddy ^{[2
]}

机构：

[1] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA

[2] Cent Univ Venezuela, Fac Med, Caracas, Venezuela

[3] Inst Resonancia Magnet, Dept Espectroscopia & Desarrollo Aplicaciones, Caracas, Venezuela

[4] Ctr Profes St Paula Torre B, Unidad Terapia Cognitiva, Caracas, Venezuela

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 2008年 / 25卷 / 05期

关键词：

fetal; brain; spectroscopy; lactate; growth; thrombophilia; pregnancy;

D O I：

10.1055/s-2008-1076603

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Proton magnetic resonance spectroscopy (MRS) is a noninvasive method to assess concentrations of different metabolites in tissues, including the brain. We evaluated a fetus with growth restriction using Doppler ultrasound and proton MRS. Doppler assessment revealed absent end diastolic flow in the umbilical artery. Diastolic flow was increased in the middle cerebral artery. Proton MRS of the fetal brain showed lactate and a low N-acetylaspartate/choline index, metabolic markers of starvation/hypoxia. Proton MRS gave us in vivo metabolic information of the brain of a fetus under starvation/hypoxic conditions. It is potentially a new tool for fetal surveillance. To our knowledge, this is the first report of cerebral lactate detection using proton MRS in a growth-restricted human fetus with no associated malformations in the English literature. Further experimental and clinical longitudinal investigations are needed to evaluate its efficacy in the clinical setting.

引用

页码：305 / 309

页数：5

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