Apoptosis and the CD95 system in HIV disease: impact of highly active anti-retroviral therapy (HAART)

被引：31

作者：

Gougeon, ML

Lecoeur, H

Sasaki, Y

机构：

[1] Inst Pasteur, Dept SIDA & Retrovirus, Unite Oncol Virale, F-75724 Paris 15, France

[2] Natl Inst Infect Dis, Dept Safety Res Biol, Tokyo 2080011, Japan

来源：

IMMUNOLOGY LETTERS | 1999年 / 66卷 / 1-3期

关键词：

apoptosis; CD95; memory; HAART;

D O I：

10.1016/S0165-2478(98)00167-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis markers and the rate of lymphocyte apoptosis were followed in the peripheral blood of HIV infected persons at various stages of disease. Our study suggests that the early increase in memory cells following therapy may also be due to a significant decrease in apoptosis in this subset. The intrinsic resistance to apoptosis in the naive subset appears to be maintained following HIV infection and is not modified following highly active anti-retroviral treatment (HAART). (C) 1999 Elsevier Science B.V. All rights reserved.

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页码：97 / 103

页数：7

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