Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment

被引：72

作者：

Crettol, Severine ^{[1
,2
]}

Besson, Jacques ^{[3
,4
]}

Croquette-Krokar, Marina ^{[5
]}

Haemmig, Robert ^{[6
]}

Gothuey, Isabelle ^{[7
]}

Monnat, Martine ^{[3
,4
]}

Deglon, Jean-Jacques ^{[8
]}

Preisig, Martin ^{[2
]}

Eap, Chin B. ^{[1
,2
]}

机构：

[1] CHU Vaudois, Dept Psychiat, Ctr Neurosci Psychiat, Unite Biochim & Psychopharmacol, CH-1008 Lausanne, Switzerland

[2] Univ Lausanne, Hop Cery, CH-1008 Lausanne, Switzerland

[3] CHU Vaudois, Dept Psychiat, Ctr St Martin, CH-1003 Lausanne, Switzerland

[4] Univ Lausanne, CH-1003 Lausanne, Switzerland

[5] Hop Univ Geneve, Div Abus Subst, CH-1205 Geneva, Switzerland

[6] Univ Psychiat Dienste Bern, CH-3000 Bern, Switzerland

[7] Unite Ambulatorie Specialisee, CH-1820 Montreux, Switzerland

[8] Fondat Phenix, CH-1224 Chene Bougeries, Switzerland

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2008年 / 32卷 / 07期

关键词：

dopamine receptor; genetic polymorphism; methadone; opioid receptor;

D O I：

10.1016/j.pnpbp.2008.07.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Genetic variations of the dopamine and opioid receptors could influence the response to methadone maintenance treatment (MMT). Methods: We included 238 MMT patients according to their response to treatment and methadone dosing, along with 217 subjects without substance dependence. All were genotyped for polymorphisms of the dopamine D-1, D-2, mu-opioid and delta-opioid receptor genes.Results: The polymorphisms of the mu-opioid (118A > G), delta-opioid (921 T > C), dopamine D-1 (Ddel) and D-2 (TaqI A) receptor genes were not associated with response to MMT and methadone dosing, whereas an association was found with the dopamine D2 receptor (DRD2) 957C > T polymorphism. The 957CC carriers were more frequently non-responders to treatment (OR=2.4; p=0.02) and presented a fourfold shorter period of negative urine screening (p=0.02). No significant differences in allele frequencies were observed between the MMT patients and the control group, suggesting no association of the analyzed polymorphisms with opioid dependence. Conclusions: These results suggest that DRD2 genotype may contribute to the understanding of the interindividual variability to the response to MMT. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：1722 / 1727

页数：6

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