NOROVIRUS ENCEPHALOPATHY IN A PREVIOUSLY HEALTHY CHILD

被引：16

作者：

Obinata, Kaoru ^{[1
,2
]}

Okumura, Akihisa ^{[3
]}

Nakazawa, Tomoyuki ^{[1
]}

Kamata, Ayako ^{[2
]}

Niizuma, Takahiro ^{[2
]}

Kinoshita, Keiji ^{[2
]}

Shimizu, Toshiaki ^{[3
]}

机构：

[1] Juntendo Univ, Urayasu Hosp, Dept Pediat, Urayasu, Chiba 2790021, Japan

[2] Koshigaya Municipal Hosp, Dept Pediat, Saitama, Japan

[3] Juntendo Univ, Fac Med, Dept Pediat, Tokyo, Japan

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2010年 / 29卷 / 11期

关键词：

norovirus; encephalopathy; neurologic involvement; INFECTION; ROTAVIRUS; PATTERNS; STRAIN;

D O I：

10.1097/INF.0b013e3181e78889

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Norovirus causes acute gastroenteritis in all age groups. Afebrile convulsion is an occasional neurologic complication in norovirus infection, but encephalitis is rare. We report the case of a previously healthy 15-month-old girl with norovirus encephalopathy who had a poor neurologic outcome. Norovirus (genogroup II) was detected in plasma and stool by real-time reverse transcription polymerase chain reaction, but the cerebrospinal fluid showed negative result for genome. Elevated concentrations of cerebrospinal fluid interleukin-6, interleukin-10, interferon-gamma, and tumor necrosis factor-alpha were observed on the third day of illness. The encephalopathy in our patient may be related to hypercytokinemia rather than to direct viral invasion.

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收藏

页码：1057 / 1059

页数：3

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