In the swim of things: recent insights to neurogenetic disorders from zebrafish

被引：47

作者：

Kabashi, Edor ^{[1
,2
,3
,4
]}

Champagne, Nathalie ^{[1
,2
,3
,4
]}

Brustein, Edna ^{[1
,2
]}

Drapeau, Pierre ^{[1
,2
]}

机构：

[1] Univ Montreal, Dept Pathol & Cell Biol, Montreal, PQ, Canada

[2] Univ Montreal, Grp Rech Syst Nerveux Cent, Montreal, PQ, Canada

[3] Univ Montreal, CHUM, Ctr Excellence Neur, Res Ctr, Montreal, PQ, Canada

[4] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada

来源：

TRENDS IN GENETICS | 2010年 / 26卷 / 08期

关键词：

AMYOTROPHIC-LATERAL-SCLEROSIS; HEREDITARY SPASTIC PARAPLEGIA; LIVE TRANSGENIC ZEBRAFISH; NEURONAL CELL-DEATH; IN-VIVO; EXPRESSION ANALYSIS; PARKINSONS-DISEASE; MISSENSE MUTATION; GENE-EXPRESSION; DRUG DISCOVERY;

D O I：

10.1016/j.tig.2010.05.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

The advantage of zebrafish as a model to study human pathologies lies in the ease of manipulating gene expression in vivo. Here we focus on recent progress in our understanding of motor neuron diseases and neurodevelopmental disorders and discuss how novel technologies will permit further disease models to be developed. Together these advances set the stage for this simple functional model, with particular advantages for transgenesis, multigenic analyses and chemical biology, to become uniquely suited for advancing the functional genomics of neurological and possibly psychiatric diseases - from understanding the genetics and cell biology of degenerative and developmental disorders to the discovery of therapeutics.

引用

页码：373 / 381

页数：9

共 75 条

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Loss of PINK1 function affects development and results in neurodegeneration in zebrafish [J].