Stem cells in the diabetic infarcted heart

被引：20

作者：

Glass, Carley E. ^{[1
]}

Singal, Pawan K. ^{[2
]}

Singla, Dinender K. ^{[1
]}

机构：

[1] Univ Cent Florida, Biomol Sci Ctr, Burnett Sch Biomed Sci, Coll Med, Orlando, FL 32816 USA

[2] Univ Manitoba, Inst Cardiovasc Sci, St Boniface Gen Hosp, Res Ctr, Winnipeg, MB, Canada

来源：

HEART FAILURE REVIEWS | 2010年 / 15卷 / 06期

关键词：

Diabetes; Embryonic stem cells; Myocardial infarction; Oxidative stress; Hyperglycemia; ACUTE MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; ANIMAL-MODELS; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; CARDIAC-FUNCTION; APOPTOSIS; MECHANISMS; HYPERGLYCEMIA;

D O I：

10.1007/s10741-010-9172-8

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant advances in pharmacological interventions and surgical techniques, the disease progression leading to diabetic end-stage heart failure remains very high. Recently, cell therapy has gained much attention as an alternative approach to treat various heart diseases. However, transplanted stem cell studies in diabetic animal models are very limited. In this review, we discuss the pathogenesis of the diabetic infarcted heart and the potential of stem cell therapy to repair and regenerate.

引用

页码：581 / 588

页数：8

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