Microarray analysis identifies interferon β-regulated genes in multiple sclerosis

被引：68

作者：

Koike, F

Satoh, J

Miyake, S

Yamamoto, T

Kawai, M

Kikuchi, S

Nomura, K

Yokoyama, K

Ota, K

Kanda, T

Fukazawa, T

Yamamura, T

机构：

[1] Natl Inst Neurosci, Dept Immunol, Kodaira, Tokyo 1878502, Japan

[2] NCNP, Natl Ctr Hosp Mental Nervous & Muscular Disorders, Kodaira, Tokyo 1878502, Japan

[3] Hokkaido Univ, Grad Sch Med, Dept Neurol, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[4] Saitama Med Sch, Dept Neurol, Moroyama, Saitama 3500495, Japan

[5] Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 113841, Japan

[6] Tokyo Womens Med Coll, Dept Neurol, Tokyo 1628666, Japan

[7] Tokyo Med & Dent Univ, Dept Neurol, Bunkyo Ku, Tokyo 1138519, Japan

[8] Hokuyukai Neurol Hosp, Nishi Ku, Sapporo, Hokkaido 0630802, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 139卷 / 1-2期

关键词：

interferon beta; interferon beta-regulated genes; microarray; multiple sclerosis;

D O I：

10.1016/S0165-5728(03)00155-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The molecular mechanisms for the interferon beta (IFNbeta) treatment of multiple sclerosis (MS) remain to be characterized. Using cDNA microarray technology, we have compared the gene expression profile of T and non-T cells derived from relapsing-remitting MS before and after treatment with IFNbeta-1b. IFNbeta treatment significantly altered expression of 21 genes out of 1263 at 3 and 6 months after treatment. These genes included nine with IFN-responsive promoter elements. Whereas there was no change in Th1 or Th2 marker genes, some of the changes were unexpected but coincided with the beneficial effect of IFNbeta in MS. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：109 / 118

页数：10

共 55 条

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