Functional roles of protein interactions with AMPA and kainate receptors

被引：35

作者：

Collingridge, GL ^{[1
]}

Isaac, JTR

机构：

[1] Univ Bristol, Sch Med Sci, Dept Anat, MRC Ctr Synapt Plast, Bristol BS8 1TD, Avon, England

[2] Univ British Columbia, Dept Med, Brain Res Ctr, Vancouver, BC V6T 1Z3, Canada

来源：

NEUROSCIENCE RESEARCH | 2003年 / 47卷 / 01期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

long-term depression; LTD; long-term potentiation; LTP; hippocampus; glutamate; NSF; AP2; ABP; GRIP; PICK1; protein kinase C;

D O I：

10.1016/S0168-0102(03)00160-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The glutamate receptor subtypes AMPA and kainate are involved in synaptic transmission and synaptic plasticity in the CNS. Recently there has been considerable interest in understanding the molecular regulation of these receptors by proteins that directly bind to AMPA and kainate receptor subunits. Amongst the first interaction partners to be discovered were NSF, ABP, GRIP and PICK1. which bind the AMPA receptor subunit GLU(A2). We have studied the functional roles of the interactions of these proteins in regulating AMPA receptor-mediated synaptic transmission and synaptic plasticity in the hippocampus. We have also started to investigate the functions of PICK1 and GRIP on kainate receptor-mediated synaptic transmission in this region. In this article we reflect upon this work, which has led to some new ideas about how AMPA and kainate receptors are regulated at synapses. (C) 2003 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：3 / 15

页数：13

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