Prevalence and characteristics of asymptomatic norovirus infection in the community in England

被引：73

作者：

Phillips, G. ^{[1
]}

Tam, C. C. ^{[1
]}

Rodrigues, L. C. ^{[1
]}

Lopman, B. ^{[1
]}

机构：

[1] London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, Infect Dis Epidemiol Unit, London WC1E 7HT, England

来源：

EPIDEMIOLOGY AND INFECTION | 2010年 / 138卷 / 10期

关键词：

Asymptomatic viral infections; England; infectious disease epidemiology; norovirus; prevalence; REVERSE TRANSCRIPTION-PCR; NORWALK-LIKE VIRUSES; INTESTINAL DISEASE; ENTERIC PATHOGENS; GASTROENTERITIS; TRANSMISSION; NETHERLANDS; OUTBREAK; SAMPLES; HOME;

D O I：

10.1017/S0950268810000439

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Norovirus is a major cause of infectious intestinal disease, and a substantial prevalence of asymptomatic infection has been reported. We describe the prevalence, seasonality and characteristics of asymptomatic norovirus infection in England. Healthy individuals were recruited at random from the general population during the Study of Infectious Intestinal Disease (1993-1996). Norovirus was identified using real-time RT-PCR. The age-adjusted prevalence of asymptomatic norovirus infection was 12%; prevalence was highest in children aged <5 years and showed wintertime seasonality. More work is needed to understand whether asymptomatic infections are important for norovirus transmission leading to sporadic illness and outbreaks.

引用

页码：1454 / 1458

页数：5

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