Lycopene in association with α-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells

被引:117
作者
Pastori, M
Pfander, H
Boscoboinik, D
Azzi, A
机构
[1] Univ Bern, Inst Biochem & Mol Biol, CH-3012 Bern, Switzerland
[2] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland
关键词
D O I
10.1006/bbrc.1998.9351
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effect of lycopene alone or in association with other antioxidants was studied on the growth of two different human prostate carcinoma cell lines (the androgen insensitive DU-145 and PC-3), It was found that lycopene alone was not a potent inhibitor of prostate carcinoma cell proliferation. However, the simultaneous addition of lycopene together with alpha-tocopherol, at physiological concentrations (less than 1 mu M and 50 mu M, respectively), resulted in a strong inhibitory effect of prostate carcinoma cell proliferation, which reached values close to 90 %, The effect of lycopene with alpha-tocopherol was synergistic and was not shared by beta-tocopherol, ascorbic acid and probucol. (C) 1998 Academic Press.
引用
收藏
页码:582 / 585
页数:4
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