Are proteins made from a limited parts list?

被引：59

作者：

Fitzkee, NC ^{[1
]}

Fleming, PJ ^{[1
]}

Gong, HP ^{[1
]}

Panasik, N ^{[1
]}

Street, TO ^{[1
]}

Rose, GD ^{[1
]}

机构：

[1] Johns Hopkins Univ, Jenkins Dept Biophys, Baltimore, MD 21218 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 02期

关键词：

D O I：

10.1016/j.tibs.2004.12.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Understanding the process of protein folding has been recognized as an important challenge for >70 years. It is, quintessentially, a thermodynamic problem and, arguably, thermodynamics is our most powerful discipline for understanding biological systems. Yet, despite all this, we still lack predictive understanding of protein folding. Is something missing from this picture?

引用

页码：73 / 80

页数：8

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