The Acute Respiratory Distress Syndrome: From Mechanism to Translation

被引：303

作者：

Han, SeungHye ^{[1
]}

Mallampalli, Rama K. ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Dept Med, Acute Lung Injury Ctr Excellence, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Cell Biol & Physiol, Pittsburgh, PA 15213 USA

[3] Vet Affairs Pittsburgh Healthcare Syst, Med Specialty Serv Line, Pittsburgh, PA 15240 USA

来源：

JOURNAL OF IMMUNOLOGY | 2015年 / 194卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ACUTE LUNG INJURY; NEUTROPHIL EXTRACELLULAR TRAPS; MESENCHYMAL STEM-CELLS; PATTERN-RECOGNITION RECEPTORS; DIAGNOSED MULTIPLE-MYELOMA; MOLECULAR-PATTERNS; MITOCHONDRIAL-DNA; CLINICAL-TRIAL; SYNDROME ARDS; INFLAMMATION;

D O I：

10.4049/jimmunol.1402513

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory failure that is characterized by inflammatory injury to the alveolar capillary barrier, with extravasation of protein-rich edema fluid into the airspace. Although many modalities to treat ARDS have been investigated over the past several decades, supportive therapies remain the mainstay of treatment. In this article, we briefly review the definition, epidemiology, and pathophysiology of ARDS and present emerging aspects of ARDS pathophysiology that encompass modulators of the innate immune response, damage signals, and aberrant proteolysis that may serve as a foundation for future therapeutic targets.

引用

页码：855 / 860

页数：6

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