A novel repressor of P element transposition in Drosophila melanogaster

被引：3

作者：

Badge, RM ^{[1
]}

Brookfield, JFY ^{[1
]}

机构：

[1] Univ Nottingham, Queens Med Ctr, Dept Genet, Nottingham NG7 2UH, England

来源：

GENETICS RESEARCH | 1998年 / 71卷 / 01期

关键词：

D O I：

10.1017/S0016672397003066

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have discovered, in an inbred line (Loua) of Drosophila melanogaster from Zaire, a third chromosome showing unusual P element repression. Repression of P element transposition by this chromosome, named Loua3, is dominant zygotic and has three unusual properties. Firstly, its repression of the gonadal dysgenesis caused by a strong P haplotype is strongly temperature-dependent, being most evident at higher rearing temperatures. Secondly, subdivision of Loua3 by recombination abolishes repression: the effect is apparently a function of the intact chromosome. Finally, Loua3 also diminishes somatic lethality when chromosomes carrying many 'ammunition' elements (Birmingham2) are exposed to the constitutive transposase source Delta 2-3(99B). The chromosome has 17 P elements, none full-length, located in at least 12 dispersed positions.

引用

页码：21 / 30

页数：10

共 16 条

[1]

ANDREWS JD, 1995, GENETICS, V141, P587

[2]

ASHBURNER M, 1989, DROSOPHILA LAB MANUA, P108

[3] KP ELEMENTS REPRESS P-INDUCED HYBRID DYSGENESIS IN DROSOPHILA-MELANOGASTER [J].

BLACK, DM ;

JACKSON, MS ;

KIDWELL, MG ;

DOVER, GA .

EMBO JOURNAL, 1987, 6 (13) :4125-4135

[4] ESTIMATION OF MUTATION-RATES WHEN PREMEIOTIC EVENTS ARE INVOLVED [J].

ENGELS, WR .

ENVIRONMENTAL MUTAGENESIS, 1979, 1 (01) :37-43

[5]

GLOOR GB, 1993, GENETICS, V135, P81

[6] A PARTICULAR P-ELEMENT INSERTION IS CORRELATED TO THE P-INDUCED HYBRID DYSGENESIS REPRESSION IN DROSOPHILA-MELANOGASTER [J].

HIGUET, D ;

ANXOLABEHERE, D ;

NOUAUD, D .

GENETICAL RESEARCH, 1992, 60 (01) :15-24

[7]

KIDWELL MG, 1977, GENETICS, V86, P813

[8] TISSUE-SPECIFICITY OF DROSOPHILA P-ELEMENT TRANSPOSITION IS REGULATED AT THE LEVEL OF MESSENGER-RNA SPLICING [J].

LASKI, FA ;

RIO, DC ;

RUBIN, GM .

CELL, 1986, 44 (01) :7-19

[9]

Lee CC, 1996, MOL CELL BIOL, V16, P5616

[10] CYTOTYPE CONTROL OF DROSOPHILA-P ELEMENT TRANSPOSITION - THE 66 KD PROTEIN IS A REPRESSOR OF TRANSPOSASE ACTIVITY [J].

MISRA, S ;

RIO, DC .

CELL, 1990, 62 (02) :269-284

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