Fulminant hepatitis B associated with a specific insertion in the basal core promoter region of hepatitis B virus DNA after immunosuppressive treatment

被引：20

作者：

Gérolami, R

Henry, M

Borentain, P

Colson, P

Botta, D

Tamalet, C

机构：

[1] Hop La Timone, Virol Lab, F-13385 Marseille 5, France

[2] Hop Conception, Serv Gastroenterol & Hepatol, Marseille, France

来源：

CLINICAL INFECTIOUS DISEASES | 2005年 / 40卷 / 04期

关键词：

D O I：

10.1086/427146

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report a case of hepatitis B virus reactivation that occurred after immunosuppressive treatment in a hepatitis B surface antigen-negative patient with detectable antibodies to hepatitis B core antigen and hepatitis B surface antigen. Sequence analysis revealed an 11-bp insertion in the core promoter region of hepatitis virus DNA, creating a novel hepatocyte nuclear factor-1 binding site. This led to enhanced viral replication and fulminant hepatitis.

引用

页码：E24 / E27

页数：4

共 8 条

[1] Reactivation of hepatitis B after transplantation in patients with pre-existing anti-hepatitis B surface antigen antibodies - Report on three cases and review of the literature [J].