Liver tolerance mediated by antigen presenting cells: fact or fiction?

被引：26

作者：

Lau, AH

de Creus, A

Lu, L

Thomson, AW

机构：

[1] Univ Pittsburgh, Med Ctr, Dept Surg, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Med Ctr, Dept Immunol, Pittsburgh, PA 15213 USA

来源：

GUT | 2003年 / 52卷 / 08期

关键词：

D O I：

10.1136/gut.52.8.1075

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction are discussed. Tolerance may be facilitated by a distinctive combination of factors, linked to the unique anatomical and microenvironmental features of the liver.

引用

收藏

页码：1075 / 1078

页数：4

相关论文

共 43 条

[1] Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes [J].

Albert, ML ;

Pearce, SFA ;

Francisco, LM ;

Sauter, B ;

Roy, P ;

Silverstein, RL ;

Bhardwaj, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (07) :1359-1368

[2] Costimulatory blockade prevents early rejection, promotes lymphocyte apoptosis, and inhibits the upregulation of intragraft interleukin-6 in an orthotopic liver transplant model in the rat [J].

Bartlett, AS ;

McCall, JL ;

Ameratunga, R ;

Howden, B ;

Yeong, ML ;

Benjamin, CD ;

Hess, D ;

Peach, R ;

Munn, SR .

LIVER TRANSPLANTATION, 2002, 8 (05) :458-468

[3] Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys [J].

D'Amico, G ;

Frascaroli, G ;

Bianchi, G ;

Transidico, P ;

Doni, A ;

Vecchi, A ;

Sozzani, S ;

Allavena, P ;

Mantovani, A .

NATURE IMMUNOLOGY, 2000, 1 (05) :387-391

[4] Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells [J].

Dhodapkar, MV ;

Steinman, RM ;

Krasovsky, J ;

Munz, C ;

Bhardwaj, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (02) :233-238

[5] Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF [J].

Fadok, VA ;

Bratton, DL ;

Konowal, A ;

Freed, PW ;

Westcott, JY ;

Henson, PM .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (04) :890-898

[6] Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells [J].

Gilliet, M ;

Liu, YJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (06) :695-704

[7] HUMAN T-CELL CLONAL ANERGY IS INDUCED BY ANTIGEN PRESENTATION IN THE ABSENCE OF B7 COSTIMULATION [J].

GIMMI, CD ;

FREEMAN, GJ ;

GRIBBEN, JG ;

GRAY, G ;

NADLER, LM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6586-6590

[8] Alternative activation of macrophages [J].

Gordon, S .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (01) :23-35

[9] Identification of regulatory T cells in tolerated allografts [J].

Graca, L ;

Cobbold, SP ;

Waldmann, H .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (12) :1641-1646

[10] Induction of interleukin 10-producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells [J].

Jonuleit, H ;

Schmitt, E ;

Schuler, G ;

Knop, J ;

Enk, AH .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (09) :1213-1222

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