G-proteins and GPCRs: From the beginning

被引：10

作者：

Bourne, H. R. ^{[1
]}

机构：

[1] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

GPCRS: FROM DEORPHANIZATION TO LEAD STRUCTURE IDENTIFICATION | 2007年 / 2卷

关键词：

D O I：

10.1007/2789_2006_001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From the point of view of a participant observer, I tell the discovery stories of trimeric G-proteins and GPCRs, beginning in the 1970s. As in most such stories, formidable obstacles, confusion, and mistakes make eventual triumphs even more exciting. Because these pivotally important signaling molecules were discovered before the recombinant DNA revolution, today's well-trained molecular biologist may find it amazing that we learned anything at all.

引用

页码：1 / 21

页数：21

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