Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development

被引：21

作者：

Cormier, S

Leroy, C

Delezoide, AL

Silve, C

机构：

[1] Univ Paris 07, INSERM, U 426, F-75018 Paris, France

[2] Univ Paris 07, Inst Fed Rec 02, F-75018 Paris, France

[3] Hop Robert Debre, Assistance Publ Hop Paris, Serv Biol Dev, F-75935 Paris, France

来源：

GENE EXPRESSION PATTERNS | 2005年 / 5卷 / 04期

关键词：

FGF18; FGF23; human embryo; expression; in situ hybridization;

D O I：

10.1016/j.modgep.2004.10.008

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fibroblast Growth Factor (FGF) 18 and 23 are two recently identified members of the FGF family, a family of structurally related polypeptides with diverse roles in physiological and pathological processes. Studies mostly performed in rodents and chicken have demonstrated that FGF19 is a pleiotropic growth factor involved in the development of various organs, while there are no data supporting a direct role of FGF23 in cell proliferation or differentiation either in physiology or pathology in any species. However, it is now established that FGF23 can be a humoral messenger and an important regulator of phosphate homeostasis and vitamin D metabolism. As a first step towards elucidating the roles of these FGF in human development, we examined FGF18 and FGF23 mRNA expression by in situ hybridization in whole human embryos at 30 days and 8 weeks of gestation (GW) and in specific fetal tissues at different ages. We report a highly restricted expression pattern for both FGF genes in human embryonic development. (c) 2005 Elsevier B.V. All rights reserved.

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页码：569 / 573

页数：5

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