Beneficial effects of adenosine A2a agonist CGS-21680 in infarcted and stunned porcine myocardium

被引:69
作者
Lasley, RD [1 ]
Jahania, MS [1 ]
Mentzer, RM [1 ]
机构
[1] Univ Kentucky, Coll Med, Dept Surg, Lexington, KY 40536 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2001年 / 280卷 / 04期
关键词
adenosine A(2a) receptor; myocardial stunning; preload recruitable stroke work; myocardial infarction;
D O I
10.1152/ajpheart.2001.280.4.H1660
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although there are conflicting results on whether adenosine infusion during reperfusion alters infarct size, there are several reports that indicate adenosine A(2a) agonists reduce infarct size. There are also reports that the A(2a) agonist CGS-21680 increases cAMP and contractility in ventricular myocytes. The purpose of this study was to determine whether low-dose intracoronary infusions of CGS-21680 during reperfusion exert any beneficial effects in irreversibly and reversibly injured myocardium. Open-chest pigs were submitted to 60 min of coronary artery occlusion and 3 h of reperfusion. Treated pigs were administered intracoronary CGS-21680 (0.2 mug.kg(-1).min(-1)) for the first 60 min of reperfusion. Pigs submitted to regional stunning (15 min ischemia) were treated with intracoronary CGS-21680 (0.15 mug.kg(-1).min(-1)) after 2 h of reperfusion. In the infarct protocol, CGS-21680 reduced infarct size from 62 +/- 2% of the region at risk to 36 +/- 2%. In stunned myocardium, CGS increased load-independent regional preload recruitable stroke work and area by greater than or equal to 70%, but the same infusion in normal myocardium was associated with no inotropic effect. Both beneficial effects were associated with little systemic hemodynamic effects. These findings suggest that reperfusion infusions of low doses of the A(2a) agonist CGS-21680 exert beneficial effects in reversibly and irreversibly injured myocardium.
引用
收藏
页码:H1660 / H1666
页数:7
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