Seizure measurement in clinical trials

被引：9

作者：

Cramer, JA

机构：

[1] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

来源：

JOURNAL OF EPILEPSY | 1998年 / 11卷 / 05期

关键词：

seizures; clinical trials; clinimetric scale;

D O I：

10.1016/S0896-6974(98)00027-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The traditional endpoint in clinical trials of antiepileptic drugs has been based on counting complex partial seizures. Other aspects of seizures such as severity and precipitating factors also should be considered. A review of scales developed to assess multiple aspects of seizures is used to define additional aspects of seizures that could be measured in clinical trials. Three scales (VA Seizures Frequency and Severity Scale, Liverpool Seizure Severity Scale, and National Hospital Seizure Severity Scale) are compared for 15 aspects of seizure assessment. Nontraditional methods of seizure assessment might provide valuable data that could differentiate among treatments. (C) 1998 by Elsevier Science Inc. All rights reserved.

引用

收藏

页码：256 / 260

页数：5

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